When dueling or in certain cutscenes, John and Jack will use whichever pistol or revolver is currently equipped. Only one side-arm and one long-arm (the Sawed-off Shotgun counts as a long-arm) are visible on Marston at any one time.
The player can switch between guns of the same slot. Each weapon occupies a slot on the weapon inventory wheel.
The player can carry every weapon that is acquired in inventory, but only eight are active for selection at once.